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All times are CEST (UTC + 2)
| Brentford – Brighton | 4:2 (end) | | | Crystal Palace – Bournemouth | 0:0 (end) | | | Everton – Manchester City | 0:2 (end) |
| West Ham – Southampton | 1:1 (end) | | | Aston Villa – Newcastle | 4:1 (end) |
| Rayo Vallecano – Valencia | 1:1 (end) | | | Barcelona – Celta Vigo | 4:3 (end) | | | Mallorca – Leganés | 0:0 (end) |
| Las Palmas – Atlético | 1:0 (end) |
| RB Leipzig – Kiel | 1:1 (end) | | | Heidenheim – Bayern | 0:4 (end) | | | Bremen – Bochum | 1:0 (end) |
| Freiburg – Hoffenheim | 3:2 (end) | | | Mohuč – Wolfsburg | 2:2 (end) | | | Union Berlín – Stuttgart | 4:4 (end) |
| Liberec – Karviná | 2:3 (end) | | | Olomouc – Č. Budějovice | 3:0 (end) | | | Slavia – Slovácko | 2:0 (end) |
| Teplice – Hradec Králové | 1:0 (end) | | | Mladá Boleslav – Jablonec | 0:1 (end) | | | Pardubice – Sparta | 1:2 (end) |
| Plzeň – Dukla Praha | 4:2 (end) | | | Ostrava – Bohemians 1905 | 1:0 (end) |
final
West Ham United
1:1
(0:0)
Southampton FC
Goals:
47. Bowen (Füllkrug) – 90+3. Ugochukwu
Ball possession: 51 % : 49 %.
Shots on target: 4:4. Shots off target: 8:10. Corners: 2:5. Offsides: 1:1. Fouls: 14:13.
Referees: Kitchen – Bennett, Robathan
Attendance:
Cards: 23. Coufal (WHU), 83. Kilman (WHU) – 35. Onuachu (SOT)
Penalty missed:
Ball possession: 51 % : 49 %.
Shots on target: 4:4. Shots off target: 8:10. Corners: 2:5. Offsides: 1:1. Fouls: 14:13.
West Ham United:
Aréola – Coufal, Kilman, Todibo, Palmieri (80. Scarles) – Ward-Prowse (86. Mavropanos), C. Soler – Paquetá, Kudus (75. Guilherme), Bowen (C) (86. Ferguson) – Füllkrug (80. Souček).
Subs: Fabiański – Cresswell, Rodríguez, Irving.
Coach: Graham Potter
Southampton FC: Ramsdale – Harwood-Bellis (86. Stewart), Bednarek, Stephens (C) – Walker-Peters, Downes, M. Fernandes, Ugochukwu, Manning (86. Welington) – Onuachu (69. Archer), Sulemana (74. Dibling).
Subs: McCarthy – Aribo, Smallbone, Bree, N. Wood.
Coach: Simon Rusk
Subs: Fabiański – Cresswell, Rodríguez, Irving.
Coach: Graham Potter
Southampton FC: Ramsdale – Harwood-Bellis (86. Stewart), Bednarek, Stephens (C) – Walker-Peters, Downes, M. Fernandes, Ugochukwu, Manning (86. Welington) – Onuachu (69. Archer), Sulemana (74. Dibling).
Subs: McCarthy – Aribo, Smallbone, Bree, N. Wood.
Coach: Simon Rusk
Referees: Kitchen – Bennett, Robathan
Attendance:
Ryan Manning is replaced by Welington,
Taylor Harwood-Bellis is replaced by Ross Stewart.
James Ward-Prowse is replaced by Konstantinos Mavropanos,
Jarrod Bowen is replaced by Evan Ferguson.
Emerson Palmieri is replaced by Oliver Scarles,
Niclas Füllkrug is replaced by Tomáš Souček.
Mohammed Kudus is replaced by Luis Guilherme.
Kamaldeen Sulemana is replaced by Tyler Dibling.
Paul Onuachu is replaced by Cameron Archer.