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All times are CEST (UTC + 2)
| Heidenheim – København | 1:3 (after OT) | | | Betis – Gent | 0:1 (end) | | | Ljubljana – Banja Luka | 0:0 (end) |
| Pafos – Omonia Nikósie | 2:1 (end) | | | Jagiellonia – Bačka Topola | 3:1 (end) | | | APOEL – Celje | 0:2 (end) |
| Panathinaikos – Víkingur Reykjavík | 2:0 (end) | | | Shamrock – Molde | 0:1 (4:5 after SO) |
| Bodø/Glimt – Twente | 5:2 (after OT) | | | Galatasaray AŞ – Alkmaar | 2:2 (end) | | | FCSB – PAOK | 2:0 (end) |
| Roma – Porto | 3:2 (end) | | | Real Sociedad – Midtjylland | 5:2 (end) | | | Anderlecht – Fenerbahçe | 2:2 (end) |
| Plzeň – Ferencváros | 3:0 (end) | | | Ajax – Saint-Gilloise | 1:2 (after OT) |
final
Real Betis 
0:1
(0:0)
KAA Gent |
83. Vitor Roque (RBE)
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83
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Red card for team Real Betis (Vitor Roque).
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40
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Yellow card for team KAA Gent (Leandro Da Silva Lopes).
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23
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Yellow card for team Real Betis (Ezequiel Ávila).
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Goals:
87. Brown (Sonko)
Ball possession: 50 % : 50 %.
Shots on target: 7:1. Shots off target: 5:4. Corners: 6:4. Offsides: 1:5. Fouls: 5:16.
Referees: D. Sylwestrzak – P. Sokolnicki, A. Karasewicz (všichni POL)
Attendance: 51 510
Cards: 23. Ávila (RBE) – 40. L. Lopes (GNT) 83. Roque (RBE)
Penalty missed:
Ball possession: 50 % : 50 %.
Shots on target: 7:1. Shots off target: 5:4. Corners: 6:4. Offsides: 1:5. Fouls: 5:16.
Real Betis:
Vieites – Sabaly (59. Ruibal), Llorente (C) (46. Bartra), Natan, Perraud – Ávila, Altimira (59. Cardoso), Flores (80. Pérez Guerrero), Ezzalzouli – Roque, Antony (59. Isco).
Subs: Adrián, García – R. Rodríguez, J. Rodríguez.
Coach: M. Pellegrini.
KAA Gent: Roef – De Meyer, Watanabe (C), Torunarigha – Sonko (88. Araujo), Itō (74. de Vlieger), L. Lopes (61. Kums), Brown – Delorge – Goore (61. Vanzeir), Surdez (75. Gudjohnsen).
Subs: De Schrevel, Evers – Gambor, Gandelman, Samoise, H. Varela.
Coach: D. Milicevic.
Subs: Adrián, García – R. Rodríguez, J. Rodríguez.
Coach: M. Pellegrini.
KAA Gent: Roef – De Meyer, Watanabe (C), Torunarigha – Sonko (88. Araujo), Itō (74. de Vlieger), L. Lopes (61. Kums), Brown – Delorge – Goore (61. Vanzeir), Surdez (75. Gudjohnsen).
Subs: De Schrevel, Evers – Gambor, Gandelman, Samoise, H. Varela.
Coach: D. Milicevic.
Referees: D. Sylwestrzak – P. Sokolnicki, A. Karasewicz (všichni POL)
Attendance: 51 510
13.02.2025
Gent - Betis 0:3
Shots on target: 1:8. Shots off target: 6:6. Corners: 5:8. Offsides: 2:0. Fouls: 19:14.
Gent - Betis 0:3
Goals: 47. Antony (Sabaly), 72. Bakambu (Isco), 84. Altimira (Bakambu)
Cards: 61. Vanzeir (GNT) – 14. Sabaly (RBE)
Ball possession: 51 % : 49 %.Shots on target: 1:8. Shots off target: 6:6. Corners: 5:8. Offsides: 2:0. Fouls: 19:14.