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| Gent – Molde | 2:1 (end) | | | Djurgården – Guimarães | 1:2 (end) | | | APOEL – Banja Luka | 0:1 (end) |
| Rapid – Noah | 1:0 (end) | | | Hearts – Omonia Nikósie | 2:0 (end) | | | Pan. Ateny – Chelsea | 1:4 (end) |
| Jagiellonia – Petrocub Hîncești | 2:0 (end) | | | Celje – Başakşehir | 5:1 (end) | | | Larne – Shamrock | 1:4 (end) |
| Betis – København | 1:1 (end) | | | Helsinki – Dinamo Minsk | 1:0 (end) | | | Ljubljana – Linec | 2:0 (end) |
| New Saints – Astana | 2:0 (end) | | | Mladá Boleslav – Lugano | 0:1 (end) | | | Bačka Topola – Legia | 0:3 (end) |
| Pafos – Heidenheim | 0:1 (end) |
| Roma – Dynamo Kyiv | 1:0 (end) | | | Ferencváros – Nice | 1:0 (end) | | | Frankfurt – RFS Riga | 1:0 (end) |
| Qarabağ FK – Ajax | 0:3 (end) | | | Maccabi Tel Aviv – Real Sociedad | 1:2 (end) | | | PAOK – Plzeň | 2:2 (end) |
| Anderlecht – Ludogorec | 2:0 (end) | | | Bilbao – Slavia | 1:0 (end) | | | Porto – Hoffenheim | 2:0 (end) |
| Fenerbahçe – Man Utd. | 1:1 (end) | | | Lyon – Beşiktaş | 0:1 (end) | | | Malmö – Olympiacos | 0:1 (end) |
| Rangers – FCSB | 4:0 (end) | | | Tottenham – Alkmaar | 1:0 (end) | | | Twente – Lazio | 0:2 (end) |
final
FK Mladá Boleslav 
0:1
(0:1)
FC Lugano 
Goals:
38. Steffen
Ball possession: 45 % : 55 %.
Shots on target: 6:5. Shots off target: 3:2. Corners: 5:3. Offsides: 1:3. Fouls: 14:10.
Referees: Theouli – Kalogirou, Georgiou (CYP)
Attendance: 2836
Cards: 77. Hajdari (LUG), 90+7. Bottani (LUG)
Penalty missed: 79. Vydra (MBL), keeper Saipi saved, 81. Vydra (MBL), keeper Saipi saved
Ball possession: 45 % : 55 %.
Shots on target: 6:5. Shots off target: 3:2. Corners: 5:3. Offsides: 1:3. Fouls: 14:10.
FK Mladá Boleslav:
Trmal – Král, Suchý (C), Králik – Kostka, Sakala (65. Stránský), Vydra, Fulnek (84. Marecek) – Kušej, Ladra (88. Vojta), Mašek.
Subs: Floder, Mikulec – Donát, Kadlec, Langhamer, Matějovský, Penner, Jawo, Pulkrab.
Coach: Brännström
FC Lugano: Saipi – Brault, Papadopoulos, Hajdari, Marques – Doumbia (C), Grgic (84. Mahmúd), Bislimi (90+1. Dos Santos) – Steffen (90+1. Mai), Aliseda (74. Bottani), Mahou (74. Przybyłko).
Subs: Osigwe, Mina – Cimignani, El Wafi, Vladi.
Coach: Croci-Torti
Subs: Floder, Mikulec – Donát, Kadlec, Langhamer, Matějovský, Penner, Jawo, Pulkrab.
Coach: Brännström
FC Lugano: Saipi – Brault, Papadopoulos, Hajdari, Marques – Doumbia (C), Grgic (84. Mahmúd), Bislimi (90+1. Dos Santos) – Steffen (90+1. Mai), Aliseda (74. Bottani), Mahou (74. Przybyłko).
Subs: Osigwe, Mina – Cimignani, El Wafi, Vladi.
Coach: Croci-Torti
Referees: Theouli – Kalogirou, Georgiou (CYP)
Attendance: 2836
Scorer is RENATO STEFFEN.