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| Bilbao – Getafe | 1:1 (end) | | | Betis – Girona | 1:1 (end) |
| Lincoln – Dinamo Minsk | 2:1 (end) | | | Rapid – Trabzonspor | 2:0 (end) | | | Elfsborg – Rijeka | 2:0 (end) |
| Plzeň – Kryvbas | 1:0 (end) | | | Ajax – Panathinaikos | 0:1 (13:12 after SO) | | | Maccabi Tel Aviv – FK Ponevěž | 3:0 (end) |
| Lugano – Partizan Bělehrad | 2:2 (after OT) | | | Servette FC – Braga | 1:2 (end) | | | Banja Luka – KÍ Klaksvík | 3:1 (after OT) |
| Shamrock – Celje | 3:1 (after OT) |
| Flora – Víkingur Reykjavík | 1:2 (end) | | | Pjunik – Ordabasy | 1:0 (end) | | | Sabah Baku – St Patrick´s | 0:1 (end) |
| Legia – Brøndby | 1:1 (end) | | | Zirä FK – Osijek | 2:2 (2:1 after SO) | | | Be'er Sheva – Mladá Boleslav | 2:4 (end) |
| Brann – St. Mirren | 3:1 (end) | | | Pafos – CSKA 1948 | 4:0 (after OT) | | | Djurgården – Tampereen Ilves | 3:1 (end) |
| Kluž – Maccabi Petah Tikva | 1:0 (end) | | | Ostrava – København | 1:0 (1:2 after SO) | | | FC Sheriff – Ljubljana | 0:1 (end) |
| AEK Atény – Noah | 1:0 (end) | | | Başakşehir – Iberia 1999 | 2:0 (end) | | | Vojvodina – Maribor | 1:0 (2:4 after SO) |
| Drita – Auda | 3:1 (after OT) | | | Zrinjski Mostar – Botev Plovdiv | 2:0 (end) | | | Wisła – Trnava | 3:1 (12:11 after SO) |
| Gent – Silkeborg | 3:2 (after OT) | | | Larne – FC Ballkani | 0:1 (4:1 after SO) | | | Dečić – Helsinki | 2:1 (3:4 after SO) |
| Puskás Akadémia – Ararat-Armenia | 3:3 (end) | | | Hajduk Split – Ružomberok | 0:1 (end) |
final
Real Betis
1:1
(1:0)
Girona FC
Goals:
6. Bartra (Fekir) – 72. Misehouy (Almena)
Ball possession: 42 % : 58 %.
Shots on target: 4:2. Shots off target: 9:7. Corners: 4:4. Offsides: 1:3. Fouls: 9:7.
Referees: Ortiz – Garrido, Santiago
Attendance:
Cards: 83. Perraud (RBE)
Penalty missed:
Ball possession: 42 % : 58 %.
Shots on target: 4:2. Shots off target: 9:7. Corners: 4:4. Offsides: 1:3. Fouls: 9:7.
Real Betis:
R. Silva – Sabaly, Bartra, D. Llorente, Perraud – Carvalho (79. Cardoso), M. Roca (79. S. Altimira) – Fornals (59. R. Sánchez), Fekir (C), Juanmi (59. Ezzalzouli) – Ruibal (70. Ávila).
Subs: Adrián, Vieites – Bellerín, Diao, Losada, R. Rodríguez.
Coach: Manuel Pellegrini
Girona FC: Gazzaniga – A. Martínez (C), Da. López, Blind, Gutiérrez – Y. Herrera (70. Misehouy), Romeu (67. Solís), I. Martín – Portu (67. Almena), Ruiz (81. Krejčí), B. Gil (81. Stuani).
Subs: Carlos – Frances, Juanpe, J. Roca, van de Beek, Villa.
Coach: Míchel
Subs: Adrián, Vieites – Bellerín, Diao, Losada, R. Rodríguez.
Coach: Manuel Pellegrini
Girona FC: Gazzaniga – A. Martínez (C), Da. López, Blind, Gutiérrez – Y. Herrera (70. Misehouy), Romeu (67. Solís), I. Martín – Portu (67. Almena), Ruiz (81. Krejčí), B. Gil (81. Stuani).
Subs: Carlos – Frances, Juanpe, J. Roca, van de Beek, Villa.
Coach: Míchel
Referees: Ortiz – Garrido, Santiago
Attendance:
Abel Ruiz is replaced by Ladislav Krejčí,
Bryan Gil is replaced by Cristhian Stuani.
Marc Roca is replaced by Sergi Altimira,
William Carvalho is replaced by Johnny Cardoso.
Yangel Herrera is replaced by Gabriel Misehouy.
Aitor Ruibal is replaced by Ezequiel Ávila.
Oriol Romeu is replaced by Jhon Solís,
Portu is replaced by Iker Almena.
Pablo Fornals is replaced by Rodrigo Sánchez,
Juanmi is replaced by Abde Ezzalzouli.