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All times are CEST (UTC + 2)
| Bilbao – Getafe | 1:1 (end) | | | Betis – Girona | 1:1 (end) |
| Lincoln – Dinamo Minsk | 2:1 (end) | | | Rapid – Trabzonspor | 2:0 (end) | | | Elfsborg – Rijeka | 2:0 (end) |
| Plzeň – Kryvbas | 1:0 (end) | | | Ajax – Panathinaikos | 0:1 (13:12 after SO) | | | Maccabi Tel Aviv – FK Ponevěž | 3:0 (end) |
| Lugano – Partizan Bělehrad | 2:2 (after OT) | | | Servette FC – Braga | 1:2 (end) | | | Banja Luka – KÍ Klaksvík | 3:1 (after OT) |
| Shamrock – Celje | 3:1 (after OT) |
| Flora – Víkingur Reykjavík | 1:2 (end) | | | Pjunik – Ordabasy | 1:0 (end) | | | Sabah Baku – St Patrick´s | 0:1 (end) |
| Legia – Brøndby | 1:1 (end) | | | Zirä FK – Osijek | 2:2 (2:1 after SO) | | | Be'er Sheva – Mladá Boleslav | 2:4 (end) |
| Brann – St. Mirren | 3:1 (end) | | | Pafos – CSKA 1948 | 4:0 (after OT) | | | Djurgården – Tampereen Ilves | 3:1 (end) |
| Kluž – Maccabi Petah Tikva | 1:0 (end) | | | Ostrava – København | 1:0 (1:2 after SO) | | | FC Sheriff – Ljubljana | 0:1 (end) |
| AEK Atény – Noah | 1:0 (end) | | | Başakşehir – Iberia 1999 | 2:0 (end) | | | Vojvodina – Maribor | 1:0 (2:4 after SO) |
| Drita – Auda | 3:1 (after OT) | | | Zrinjski Mostar – Botev Plovdiv | 2:0 (end) | | | Wisła – Trnava | 3:1 (12:11 after SO) |
| Gent – Silkeborg | 3:2 (after OT) | | | Larne – FC Ballkani | 0:1 (4:1 after SO) | | | Dečić – Helsinki | 2:1 (3:4 after SO) |
| Puskás Akadémia – Ararat-Armenia | 3:3 (end) | | | Hajduk Split – Ružomberok | 0:1 (end) |
final
Athletic Bilbao
1:1
(1:0)
Getafe CF
Goals:
27. Sancet (Guruzeta) – 64. Uche (L. Milla)
Ball possession: 61 % : 39 %.
Shots on target: 4:2. Shots off target: 1:6. Corners: 5:6. Offsides: 2:6. Fouls: 13:12.
Referees: Muñiz – Blanco, Alonso
Attendance:
Cards: 55. Prados (ATB), 70. U. Gómez (ATB), 73. Gorosabel (ATB), 86. A. Herrera (ATB) – 45+8. Uche (GET)
Penalty missed:
Ball possession: 61 % : 39 %.
Shots on target: 4:2. Shots off target: 1:6. Corners: 5:6. Offsides: 2:6. Fouls: 13:12.
Athletic Bilbao:
Padilla – Gorosabel (81. Lekue), Y. Álvarez, Paredes (81. Vivian), Berchiche – Prados (57. A. Herrera), Vesga (57. U. Gómez) – I. Williams (C), Sancet, Berenguer (72. N. Williams) – Guruzeta.
Subs: Gastesi – Ares, Boiro, Egiluz, Jauregizar, Martón.
Coach: Ernesto Valverde
Getafe CF: Soria – Aberdin, Dakonam (C), Alderete – J. Iglesias, L. Milla, M. Arambarri (40. Aleñá), Rico – C. Pérez (46. Federico), Sola (79. Santiago) – Uche.
Subs: Letáček, Ferrer – Risco, Duarte.
Coach: José Bordalás
Subs: Gastesi – Ares, Boiro, Egiluz, Jauregizar, Martón.
Coach: Ernesto Valverde
Getafe CF: Soria – Aberdin, Dakonam (C), Alderete – J. Iglesias, L. Milla, M. Arambarri (40. Aleñá), Rico – C. Pérez (46. Federico), Sola (79. Santiago) – Uche.
Subs: Letáček, Ferrer – Risco, Duarte.
Coach: José Bordalás
Referees: Muñiz – Blanco, Alonso
Attendance:
Aitor Paredes is replaced by Daniel Vivian,
Andoni Gorosabel is replaced by Iñigo Lekue.
Álex Sola is replaced by Yellu Santiago.
Álex Berenguer is replaced by Nico Williams.
Beñat Prados is replaced by Ander Herrera,
Mikel Vesga is replaced by Unai Gómez.
Carles Pérez is replaced by Peter Federico.
Mauro Arambarri is replaced by Carles Aleñá.